产品类别

 兔抗人、大、小鼠ADFP蛋白抗体

产品价格

 0.2ml/890元  

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

    Adipophilin（ADFP）是一种脂滴周围主要的相关蛋白，它大量分布在脂质蓄积正常或不正常的细胞中，是脂质蓄积的一个特异性标记物。它在脂肪细胞分化早期就有很高的表达，但当脂肪细胞成熟后，它的表达就明显减少，故称；脂肪分化相关蛋白。
    ADFP在很多组织器官中都发挥重要作用，它不仅参与脂肪细胞的脂质代谢、脂滴的形成及肝内三酰甘油（TO）的合成与代谢，还能促进巨噬细胞、平滑肌细胞的泡沫化，长链脂肪酸的摄取，乳汁的分泌等。
    ADFP的表达异常与动脉粥样硬化、胰岛素抵抗和肿瘤等病理过程密切相关。

    Milk lipid globules from humans, cows and rats contain a protein identified as adipocyte differentiation-related protein (ADFP) associated with the globule surface membrane material. This protein, previously believed to be specific to adipocytes, was a major constituent of the globule surface and was present in a detergent-insoluble complex that contained stoichiometric amounts of butyrophilin and xanthine oxidase. ADFP (Adipophilin) occurs in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. ADFP may be a possible new marker for the identification of specialized differentiated cells containing lipid droplets and for diseases associated with fat-accumulating cells.
    mol wt:48kDa
    Other Aliases:
    adipophilin; Adipose differentiation related protein; ADRP; MGC10598.