产品类别

 兔抗人、大、小鼠AHR抗体

克 隆 号

 浓缩液(1mg/1ml) 亲和纯化抗体

产品价格

 0.2ml/1280元  

产品标准

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500

产品应用

 （石蜡切片需做抗原修复）

 

产品介绍

Chromatin and Nuclear Signaling (染色质和核信号)

Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
     [SUBCELLULAR LOCATION] Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
     [TISSUE SPECIFICITY] Expressed in all tissues tested including brain, heart, kidney, liver, lung, muscle, ovary, skin, spleen and thymus.
    mol wt:93kDa
    Other Aliases:
    aryl hydrocarbon receptor; Ah receptor; Aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor;BHLHE76; Class E basic helix loop helix protein 76; HGNC:348.