产品类别

 兔抗人、大、小鼠Apelin蛋白抗体

产品价格

 0.2ml/1280元  

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

 

   脂肪炎症因子apelin是血管紧张素Ⅱ-1型受体相关蛋白的天然内源性配体，是新发现的小分子活性多肽，为孤儿G蛋白偶联受体一血管紧张素受体AT-1相关蛋白(APJ)的天然配体具有调节心血管系统稳态、扩张血管、降低血压、调节免疫等多种生物学作用。

  Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.
    mol wt:10kDa
    Other Aliases:
    APLN; Apel; AGTRL1 ligand ; APEL; APJ endogenous ligand; XNPEP2