产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
转录调节因子（Transcriptin Regulators）
APEX(Ref-1)是一种多功能蛋白,除了修复AP位点外,还保持很多转录因子包括AP-1、NF-κB、CREB、ATF、myb、Pax、HIF-1α、HLF、Egr-1、NF-Y、p53和PEBP2等活性还原状态,对维持DNA的稳定和调节细胞因子的表达具有重要作用.
APE1是一种具有DNA修复、氧化还原以及调节转录因子活性的多功能蛋白, APE在多种细胞抗氧化损伤过程中起重要的作用。
Ref-1在体内是一种广泛表达的基因,胞质、胞核及胞质和胞核同时表达三种表达模式,与细胞的分化成熟过程有关.APE/Ref-1蛋白的不正常表达、分布及功能改变与细胞凋亡、肿瘤发生、神经系统退行性疾病和老年化等病理过程密切相关.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Alternate Names:
AP endonuclease 1;
AP endonuclease class I;
AP lyase;
APE 1 ;
APE;
APEN ;
APEX 1
; APEX;
APEX nuclease (multifunctional DNA repair enzyme) 1;
Apex nuclease 1;
Apex nuclease;
APEX1;
Apurinic/apyrimidinic (abasic) endonuclease;
Apurinic/apyrimidinic exonuclease;
APX ;
Deoxyribonuclease (apurinic or apyrimidinic) ;
DNA (apurinic or apyrimidinic site) lyase;
HAP 1; HAP1;
Multifunctional DNA repair enzyme;
Redox factor 1;
REF 1;
REF 1 protein ;
REF1;
REF1 protein
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