产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    CD6 is a type I membrane protein expressed by thymocytes, mature T cells, a subset of B cells known as B1 cells, and some cells in the brain. CD6 is a member of the scavenger receptor cysteine rich (SRCR) family of proteins, which includes the leukocyte antigen CD5. The extracellular domain of CD6 is composed of three SRCR domains and has the same domain organization as CD5. The ligand for CD6 is CD166 also known as activated leukocyte cell adhesion molecule. Through its interaction with CD166 in the thymus, CD6 may have a role in T cell development.
    mol wt:73kDa
    Other Aliases:
    T-cell differentiation antigen CD6; CD6 antigen Tp120; OX52; T cell differentiation antigen CD6; T12; TP120
    CD6是I型整合膜糖蛋白,属于SRCRSF（ scavenger receptor cysteine-rich superfamily）成员。CD6在外周血T细胞和髓质的胸腺细胞表面表达,也表达在皮质的胸腺细胞、B1细胞、某些NK细胞、脑细胞、T细胞或B细胞的慢性白血病细胞上。 CD6参与T细胞活化,调节T细胞功能和介导细胞-细胞间的粘附。CD6分子可与TCR/CD3形成复合体，参与免疫突触（immunological synapse，IS）的形成。
    在自身性免疫性疾病发病机制中，T细胞增殖活化和迁移过程起着重要作用。基于CD6分子在淋巴细胞成熟、活化和增殖中的重要作用，阻断CD6分子的功能可为类风湿性关节炎、银屑病等自身免疫的治疗提供新的治疗手段和方法