产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
磷酸化环腺苷酸应答元件结合蛋白(p-cAMP responsive element binding protein-1, p-CREB-1)是真核细胞转录因子，属于ATF/CREB家族。参与由cAMP或某些病毒蛋白质所诱导基因转录的调节。
此抗体识别分子量为43kDa的CREB蛋白。
ATF/CREB家族相关蛋白
bs-0517R ATF-1 活化复制因子1
bs-0518R ATF-2 活化复制因子2
bs-0519R ATF-3 活化复制因子3
bs-0035M CREB 非磷酸化环腺苷酸应答元件结合蛋白（抗体）
bs-0036R P-CREB 磷酸化环腺苷酸应答元件结合蛋白（抗体）
The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein), which may reprecent a CREB co-activator.
Also known as:
Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB 1; CREB1; MGC9284; Transactivator protein
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