产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    DcR3是一个新发现的具有免疫抑制作用的分子,也属于肿瘤坏死因子受体超家族的成员。DcR3通过拮抗Fas/FasL、LIGHT/LTβR来发挥作用,在肿瘤及免疫性疾病中发挥重要作用。
    Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1and DcR2, DcR3 is a soluble rather than a membraneassociated molecule. DcR3 binds to FasL and LIGHT andinhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and coloncarcinomas and in some normal tissues.
    mol wt:33kDa
     Other Aliases:
    Decoy receptor 3; Tumor necrosis factor receptor superfamily member 6B; Decoy receptor for Fas ligand; M68