产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    凋亡相关蛋白激酶1(DAPK1)又称：一般性白血病的基因，也是一种肿瘤抑制基因，广泛存在于各种细胞的凋亡系统中，该基因正常情况下有助于触发细胞在发生癌变前就死亡。但异常的DNA甲基化作用会关闭控制细胞生长的DAPK1基因，从而造成肿瘤生长。

    DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.
    mol wt:157kDa
    Other Aliases:
    DAPK1; DAK1; DAP K1; DAPK 1; DAPK; DAPK1; Death Associated Protein Kinase 1; DKFZp781I035