产品类别

 兔抗人、大、小鼠GRM2蛋白抗体

产品价格

 0.1ml/400元  0.2ml/650元  

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

  谷氨酸受体-代谢能2；主要参与细胞信号转导及突触传递，在G蛋白偶联受体蛋白信号转导途径中有一定的作用，并且有负调控腺苷酸环化酶的作用，为膜性蛋白，在胞膜、胞浆中表达。
   L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
    mol wt:96kDa
    Also known as:
    Glutamate Receptor Metabotropic 2; Gprc1b; AMPA selective glutamate receptor 2; GLUR 2; GLUR2; GLURB; Glutamate receptor metabotropic 2; GPRC1B; GRM 2; Grm2; mGlu 2; MGlu2; MGLUR 2; Mglur2.