产品类别
鼠抗人、大、小鼠、牛、狗、猪、羊、鸡GSK-3β抗体
产品价格
0.2ml/980元
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
产品介绍
激酶和磷酸酶(Kinases and Phosphatases) GSK-3β是一个serine/threonine,proline 直接激酶,参与多个信号通路的排列,包括糖原合成和细胞黏附,GSK3β与AD病有关。此抗体识别分子量为46kDa 的GSK-3β蛋白 。
Glycogen synthase kinase-3 beta (GSK3β) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Belongs to the Ser/Thr protein kinase family. mol wt:46kDa Other Aliases: Glycogen Synthase Kinase 3 Beta; GSK 3 beta; GSK 3B; GSK3B; GSK3B protein; GSK3beta isoform
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