产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    XAF1是一个新近发现的通过与XIAP直接结合拮抗其抗凋亡作用的蛋白因子。XAF1是一个新的肿瘤抑制基因，XAF1在多种肿瘤细胞和组织中存在低表达或表达缺失。其过度表达可诱导凋亡，抑制肿瘤生长。

    XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF1 results in the neutralization of XIAP's ability to inhibit cell death. XAF1 is normally expressed in all adult and fetal tissues but is present at very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines.
    mol wt:33kDa
    Other Aliases:
    XIAP-associated factor 1; BIRC 4 binding protein; BIRC4 binding protein; BIRC4BP; HSXIAPAF 1; HSXIAPAF1; XAF 1; XIAP associated factor 1; Fbxo39; RP24-450M24.4