产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

 

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

    The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke a perception of pain which initiates appropriate protective reflexes. The receptor for capsaicin, VR1 (vanilloid receptor 1; TRPV1 is a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. The vanilloid receptor 1 protein functions both as a receptor for capsaicin and a transducter of noxious thermal stimuli. VR1 protein is localized to small-diameter sensory neurons within the dorsal root ganglia and nerve terminals in the dorsal horn.
    mol wt:92kDa
    Other Aliases:
    Capsaicin receptor; DKFZp434K0220; Osm 9 like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; TRPV 1; TRPV1; Vanilloid receptor 1; Vanilloid receptor subtype 1; VR 1; VR1.


    辣椒素受体(Vanilloid receptor subtype 1)是机体的一个重要的损伤性感受蛋白,参与了多种生理活动和病理过程，起到对中枢和外周水平疼痛的形成,还可以激活神经纤维末端的辣椒素受体,调节外周血管的舒缩,影响血压，对缺血心肌起到保护作用; VR1还参与哮喘的发生,调节胃酸的分泌,促进胃肠蠕动。另外,激活辣椒素受体,还可抑制毛干的增殖,近年来发现他介导肿瘤细胞的凋亡