产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
产品介绍
Neuronal Marker (神经细胞标志物)
酪氨酸羟化酶(TH)是儿茶酚胺类神经递质即多巴胺、去甲肾上腺素、肾上腺素生物合成过程所需的限速酶,它以四氢生物喋呤啶(BH4)为辅酶,催化酪氨酸的羟化而生成多巴(DOPA)。 已知在患帕金森病(Parkinson disease,PD)时,脑内多巴胺(dopamine,DA)的减少与此酶活性低下有关。因此对PD模型动物来说,若将TH基因植入脑内,便可以提高脑内DA水平而达到基因治疗目的. Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease. mol wt:60kDa Other Aliases: Tyrosine Hydroxylase; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase
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