产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

 

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

    LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-β receptor (LTβR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTβR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-γ, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-α and β. This protein was also demonstrated to inhibit TNF-α-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

    mol wt:26kDa
    Other Aliases:
    Tumor necrosis factor ligand superfamily member 14; CD 258; CD258; CD258 antigen; Delta transmembrane LIGHT; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; HVEM L; HVEML; Ligand for herpesvirus entry mediator; LTg; TNF14; TNFSF 14; TNFSF14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor receptor like 2; Tumor necrosis factor superfamily member 14; Tumor necrosis factor superfamily member LIGHT