产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

 

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

  主要用于2型糖尿病的研究，TCF7L2基因可能存在双重效应，抑制β细胞代偿，减小胰岛素分泌的退化。分子量；68KDa
  TCF-4, transcription factor 4, is a basic helix-turn-helix transcription factor. This protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. The gene for TCF-4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting study indicates that it is required to maintain the crypt stem cells of the small intestine. TCF4 has many different splicing isoforms and they are expressed differentially in tissues and in cancers of different stages. Studies also indicate that variant of the TCF4 gene confers an increased risk of type 2 diabetes. also known as: TCF4; SEF2; ITF2; SEF-2; ITF-2; MGC149724; SEF2-1B; PTHS; MGC149723; SEF2-1A; SEF2-1; E2-2; HMG box transcription factor 4; T-cell-specific transcription factor 4