产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
Socs2(suppressor of cytokine signaling 1) 细胞因子信号传导抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一类由细胞产生并反馈性阻断细胞因子信号转导过程的负性调节因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多种细胞因子的信号转导，对体内多种免疫反应的激活起调控作用。SOCS2异常表达与多种疾病的发病相关，在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用；对信号转导，特别是JAKSTAT通路的负调控作用已被肯定。
The eight members of the recently identified Suppressor of Cytokines Signalling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signalling in different ways.
SOCS2 is capable of inhibiting cytokine signalling by interleukin-6 (IL-6) and growth hormone. SOCS2 interacts with the phosphorylated insulin-like growth factor (IGF-I) receptor, where it may play a regulatory role in cellular growth, differentiation, and inhibition of apoptosis via the Ras and PI3K signalling pathways. In humans, SOCS2 mRNA is expressed widely in both foetal and adult tissues, including foetal kidney and adult heart, skeletal muscle, pancreas, and liver. In rats, SOCS2 mRNA exhibits high levels of expression in liver and heart, and in the mouse nervous system, SOCS2 is expressed exclusively by neurons, where it is switched on developmentally in concordance with neuronal differentiation.
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatal growth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.
mol wt:23kDa
Other Aliases:
suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; Cish2; SSI-2; SOCS2; STATI2
