产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
结构蛋白（Structural Proteins）
S100B是一组可溶性、相对低分子质量、高酸性蛋白，属神经胶质细胞特异性蛋白，亦可存在于神经纤维中。在研究肠神经系统的形态特征及结构特征中，S100B有良好的表达功能.
S100B蛋白其生理作用尚不清楚，可能与细胞内钙离子媒介的调节作用有关。S100B蛋白可存在于神经鞘瘤，成软骨细胞瘤、软骨肉瘤、骨肉瘤、神经胶质瘤、郎格罕斯细胞瘤、一些癌肿和黑素细胞肿瘤等。
在免疫组化中，除了恶性黑素瘤皮损，S100B蛋白还在良性黑素细胞痣中增加，如：蓝痣、普通后天痣、雀斑样痣、Spitz痣、气球状细胞痣、色素性梭形细胞痣和发育不良痣中表达。还有报道S100B蛋白的染色强度与肿瘤细胞的黑素含量呈负相关。结缔组织增生性的或亲神经的黑素瘤不易染色。
S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
mol wt:11kDa
Other Aliases:
NEF; Protein S100 B; S 100 protein beta chain; S 100 protein beta subunit; S100; S100 calcium binding protein B; S100 calcium binding protein beta (neural); S100 calcium binding protein beta chain; S100 protein beta chain; S100B; S100beta
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