产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

 

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

    RAP1A (rap1a; RAS-related protein-1a precursor; Rap1A-retro2; RAP1A, member of RAS oncogene family)RAS癌基因家族成员，在调节细胞增生和粘附中有重要作用.经研究发现,Rap1和它的调节子SPA-1在很多恶性肿瘤的发生、发展中起到一定的作用。定位于胞浆、胞膜。
    The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.