产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
信号传导（Signaling Intermediates）
PERK is a GCN2 Ser/Thr protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation. This results in a reduction of translational initiation and repression of global protein synthesis. Expression of this Type I membrane protein is ubiquitous at low levels but greatest expression is seen in secretory and endocrine tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), which is a rare autosomal recessive disorder.
mol wt:125kDa
Other Aliases:
DKFZp781H1925; EC 2.7.11.1; Eukaryotic translation initiation factor 2 alpha kinase 3; EIF2AK3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS
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