产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    PAI-1是一种单链糖蛋白，其生理作用很多：
    （1）与组织型纤溶酶原激活物（tissue plasminogen activator，t-PA）形成1：1的复合物而使t-PA失活;
    （2）保护基底膜不被血浆来源的酶所降解;
    （3）保护细胞间的接触面而维持组织结构的完整性;
    （4）在结缔组织演变、凝血、纤溶、补体激活和炎症反应等过程中具有抑制蛋白降解作用;
    （5）在细胞周期中，PAI-1转录水平的变化及其在细胞内的积聚，对细胞形态的维持、细胞与其间质的粘附、细胞增殖、信号转导及基因表达等都有重要意义;

    PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
    mol wt: 45 kDa
    Other Aliases:
    plasminogen activator inhibitor 1; ERPINE1; AI; LANH1; PAI-1; AI1; serpin peptidase inhibitor, clade E; nexin, plasminogen activator inhibitor type 1; prebeta-migrating plasminogen activator inhibitor; PAI precursor polypeptide