产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    鸟氨酸脱羧酶为多胺生物合成途径中的第一个限速酶 (催化合成多胺的第一步反应 ,即催化L -鸟氨酸脱羧生成腐胺 ) ,具有超常转变率和对于刺激的迅速反应性。
    多胺广泛存在于生物体的各种细胞和组织中 ,是一种重要的代谢调控物质 ,它可直接与DNA相互作用 ,调节DNA构象 ,并参与RNA及蛋白质的合成 ,与细胞增殖、分化密切相关。经研究表明 ,哺乳动物细胞增殖体现出完全的多胺依赖性。ODC主要存在于胞浆中。

    Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
    mol wt:51kDa
    Other Aliases:
    Ornithine decarboxylase 1; Ornithine decarboxylase; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 2; Ornithine decarboxylase structural 1; RNODC