产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

[FUNCTION] Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
[SUBUNIT] Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.
[SUBCELLULAR LOCATION] Nucleus (By similarity). Cell projection, pseudopodium (By similarity). Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle (By similarity).
[TISSUE SPECIFICITY] Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart.
[DEVELOPMENTAL STAGE] At E9.5, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At E15.5, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust.
[SIMILARITY] Belongs to the myozenin family.
Alternate Names: MYOZ1; Myozenin; myozenin 1; Myozenin-1; Calsarcin-2; Filamin-, actinin- and telethonin-binding protein; Protein FATZ