产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    Mcm7是微小染色体维持蛋白家族成员之一,与其他的Mcm蛋白形成异多聚体,调节DNA的复制.在启动DNA复制、合成中起到关键作用,在增殖细胞或组织表达较高,可以作为肿瘤生物标志物.

    hCDC47 is a human member of the MCM family, which allows DNA to replicate once per cell cycle. In quiescent cells, human MCM7 (hMCM7) mRNA is almost undetectable. Stimulation of cells to enter the cell cycle results in induction of hMCM7 expression. The hCDC47 protein expression and localization is found in nuclei of the proliferative components of normal lymph nodes, bone marrow, epidermis and mucosa. Malignant tumors from several organs contained more nuclear hCDC47 positive cells than their normal counterparts. These results indicate that hCDC47 may play a role in normal and neoplastic cell growth in vivo.
    mol wt:79kDa
    Other Aliases:
    minichromosome maintenance protein 7; CDABP0042; AI747533; CDC 47; CDC47; CDC47 homolog; DNA replication licensing factor MCM7; Homolog of S. cerevisiae Cdc47; MCM7 minichromosome maintenance deficient 7; Minichromosome Maintainence 7; P1.1MCM3; P1CDC47; P85MCM; PNAS 146; PNAS146; mCDC47; Mcmd7