产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
产品介绍
LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因,在哺乳动物体内广泛存在,目前发现该家族至少包括三个成员:LRIG1、LRIG2和LRIG3,是一类结构相似的跨膜糖蛋白,该蛋白人、鼠的同源性较高。 目前在肿瘤方面的研究较多,有研究认为:LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用,LRIG1在抑制肿瘤转移中具有重要作用。 LRIG3 is predicted to be a 1117 amino acid single pass transmembrane protein with 15 leucine rich repeats and 3 Ig domains in the extracellular region, and a short, novel cytoplasmic tail with no known motifs. It is believed that LRIG3 influences lateral ear canal morphogenesis. Expression and sub-cellular localization of LRIG3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. mol wt:123kDa Other Aliases: leucine rich repeats and immunoglobulin-like domains 3; LIG3; LRIG1-3
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