产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品说明

    Heregulin-α是细胞间信号蛋白,在乳腺上皮细胞形态发生、导管形成，以及诱导乳腺上皮细胞分化成分泌腺泡中起到重要作用，对乳腺发育和乳腺功能调控具有重要意义。

    Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
    mol wt:70kDa
    Other Aliases:
    HRG-α; Heregulin-α; HRG-alpha;Heregulin-alpha; NRG1; GGF; HGL; HRGA; NDF; SMDF; Pro-neuregulin-1, membrane-bound isoform;
Contains: Neuregulin-1; Neu differentiation factor; Heregulin; HRG; AltName: Breast cancer cell differentiation factor p45; Acetylcholine receptor-inducing activity; ARIA; Sensory and motor neuron-derived factor; Glial growth factor; neuregulin 1 isoform HRG-alpha