产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品说明

    Heregulin-β是细胞间信号蛋白,在乳腺上皮细胞形态发生、导管形成，以及诱导乳腺上皮细胞分化成分泌腺泡中起到重要作用，对乳腺发育和乳腺功能调控具有重要意义。

    NRG1 (Neuregulin 1) is a ligand for ERBB3 and ERBB4 tyrosine kinase receptors. NRG1 concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. There are multiple isoforms of NRG1, the type I isoforms (isoforms 1-8) have an Ig domain and a glycosylation domain. There are 10 known isoforms in total which perform distinct tissue-specific functions. Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in nonneuronal organs, whereas isoform 5 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain.
    mol wt:69kDa
    Other Aliases:
    Heregulin-β; Breast cancer cell differentiation factor p45; GGF; Glial growth factor; Heregulin; HGL; HRG; HRGA; NDF; Neu differentiation factor; Neuregulin 1; Neuregulin-1; NRG 1; NRG alpha; NRG beta; Sensory and motor neuron-derived factor; SMDF; SMDF